Can GABA turn pancreatic α-cells into β-cells?
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چکیده
منابع مشابه
Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells
The adult pancreas is capable of limited regeneration after injury but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic tissue are not well understood. Here, we show that inactivation of the SCF-type E3 ubiquitin ligase substrate recognition component Fbw7 induces pancreatic ductal cells to reprogram into α, δ, and β cells. L...
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Recently, it was demonstrated that pancreatic new-born glucagon-producing cells can regenerate and convert into insulin-producing β-like cells through the ectopic expression of a single gene, Pax4. Here, combining conditional loss-of-function and lineage tracing approaches, we show that the selective inhibition of the Arx gene in α-cells is sufficient to promote the conversion of adult α-cells ...
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BACKGROUND Evidence hints at the ability of β-cells to emerge from non-β-cells upon genetic or pharmacological interventions. However, their quantitative contributions to the process of autonomous β-cell regeneration without genetic or pharmacological manipulations remain to be determined. METHODS & RESULTS Using PANIC-ATTAC mice, a model of titratable, acute β-cell apoptosis capable of auton...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2018
ISSN: 1759-5029,1759-5037
DOI: 10.1038/s41574-018-0101-6